Tadahiko Mashino Selected Research

Fullerenes

3/2022	A pyridinium‑type fullerene derivative suppresses primary effusion lymphoma cell viability via the downregulation of the Wnt signaling pathway through the destabilization of β‑catenin.
2/2022	A bis-pyridinium fullerene derivative induces apoptosis through the generation of ROS in BCR-ABL-positive leukemia cells.
1/2022	Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells.
1/2022	[Development of Bio-active Fullerene Derivatives Suitable for Drug].
1/2019	Synthesis and antitumor activity of novel pyridinium fullerene derivatives.
10/2016	Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease.
3/2016	A proline-type fullerene derivative inhibits adipogenesis by preventing PPARγ activation.
8/2014	Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma.
1/2013	Anti-influenza activity of c60 fullerene derivatives.
11/2012	Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway.

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Tadahiko Mashino Research Topics

Disease

10	Neoplasms (Cancer) 01/2022 - 12/2003
3	Leukemia 02/2022 - 12/2008
2	Primary Effusion Lymphoma 03/2022 - 08/2014
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 02/2022 - 01/2022
2	Hepatocellular Carcinoma (Hepatoma) 12/2020 - 01/2018
2	Carcinogenesis 01/2017 - 11/2012
2	Edema (Dropsy) 09/2011 - 05/2010
2	Asthma (Bronchial Asthma) 05/2009 - 04/2009
2	Inflammation (Inflammations) 05/2009 - 04/2009
1	Rheumatoid Arthritis 04/2022
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/2022
1	Hepatitis C 01/2022
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2022
1	Drug-Related Side Effects and Adverse Reactions 11/2021
1	Coinfection 10/2021
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2018
1	Hyperuricemia 01/2017
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2017
1	Infections 10/2016
1	Obesity 03/2016
1	Lymphoma (Lymphomas) 08/2014
1	Virus Diseases (Viral Diseases) 01/2013
1	Human Influenza (Influenza) 01/2013
1	Acute Intermittent Porphyria (Porphyria, Acute) 07/2012
1	Porphyrias (Porphyria) 07/2012
1	Phototoxic Dermatitis (Phototoxicity) 06/2010
1	Necrosis 10/2009
1	Stomach Ulcer (Gastric Ulcer) 04/2009
1	Contracture 02/2002

Drug/Important Bio-Agent (IBA)

12	FullerenesIBA 03/2022 - 12/2003
5	Pharmaceutical PreparationsIBA 02/2022 - 08/2014
5	Proteins (Proteins, Gene)FDA Link 02/2022 - 12/2008
3	AntioxidantsIBA 01/2022 - 06/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 06/2010
2	CrizotinibIBA 04/2018 - 01/2017
2	Tocopherols (Tocopherol)IBA 04/2018 - 01/2017
2	Anaplastic Lymphoma KinaseIBA 04/2018 - 01/2017
2	Vitamin E FDA LinkGeneric 04/2018 - 01/2017
2	Biological ProductsIBA 12/2016 - 06/2010
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2012 - 12/2008
2	CarrageenanIBA 09/2011 - 05/2010
2	licochalcone AIBA 05/2010 - 10/2009
1	Epoxy Compounds (Epoxides)IBA 04/2022
1	tofacitinibIBA 04/2022
1	Janus Kinase InhibitorsIBA 04/2022
1	AldehydesIBA 04/2022
1	GlucuronidesIBA 11/2021
1	EstersIBA 10/2021
1	Sorafenib (BAY 43-9006)FDA Link 12/2020
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019
1	Cisplatin (Platino)FDA LinkGeneric 01/2019
1	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA 04/2018
1	TocotrienolsIBA 04/2018
1	Autophagy-Related ProteinsIBA 01/2018
1	BenzbromaroneIBA 01/2017
1	alpha-Tocopherol FDA Link 01/2017
1	Sequestosome-1 ProteinIBA 12/2016
1	EnzymesIBA 10/2016
1	Caspase 9IBA 08/2014
1	Butylated Hydroxytoluene (BHT)IBA 12/2013
1	OxindolesIBA 12/2013
1	EndonucleasesIBA 01/2013
1	NucleoproteinsIBA 01/2013
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 01/2013
1	fullerene C60IBA 01/2013
1	Janus Kinase 2IBA 11/2012
1	pyrazolanthroneIBA 11/2012
1	Heme (Haem)IBA 07/2012
1	Glucose (Dextrose)FDA LinkGeneric 07/2012
1	AcidsIBA 07/2012
1	Griseofulvin (Grifulvin V)FDA LinkGeneric 07/2012
1	ApigeninIBA 09/2011
1	fisetinIBA 09/2011
1	LuteolinIBA 09/2011
1	PolymersIBA 06/2010
1	salicylhydroxamic acid (SHAM)IBA 06/2010
1	NF-kappa B (NF-kB)IBA 10/2009
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2009
1	DNA (Deoxyribonucleic Acid)IBA 10/2009
1	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 02/2002
1	Acetylcholine (Acetylcholine Chloride)FDA Link 02/2002

Therapy/Procedure

2	Traditional Medicine (Folk Remedies) 05/2009 - 04/2009